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℡ 4000-520-616
℡ 4000-520-616
BD Biosciences/Anti-Human CD2/CD2R Purified/340366
产品编号:340366
市  场 价:¥0.00
场      地:美国(厂家直采)
产品分类: 蛋白类>多肽>多肽合成>
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品      牌: BD Biosciences
公      司:BD Biosciences,Inc.
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BD Biosciences/Anti-Human CD2/CD2R Purified/340366
商品介绍
Product DetailsRecommended AssayReferences

Description

CD2, clone L303.1, and CD2R, clone L304.1, are each derived by the fusion of SP2/0 myeloma cells with splenocytes from BALB/c mice immunized with CD3-activated human T lymphocytes.

The CD2 molecule is an Mr 50-kilodalton (kd) human lymphocyte antigen. At least three different functional epitopes of CD2 have been defined. One epitope (recognized by Leu™-5b) is the sheep red blood cell (SRBC) receptor. The other two epitopes, CD2 and CD2R, are binding sites for monoclonal antibodies that, when used together, deliver signals for polyclonal T-lymphocyte activation.

Contents

SpecificityCloneFormatIsotypeEntrez Gene ID
CD2L303.1 (also known as L303)PurifiedIgG2a, κ
CD2RL304.1PurifiedIgG1, κ914
Preparation and Storage

The monoclonal antibody is supplied as 125 μg each of CD2 and CD2R in 250 μL of phosphate-buffered saline (PBS) containing 0.01% sodium azide. The vial should be stored at 2° to 8°C. Each reagent is stable for the period shown on the bottle label when stored as directed.

  1. Huet S, Wakasugi H, Sterkers G, et al. T cell activation via CD2 (T, gp50): The role of accessory cells in activating resting T cells via CD2. J Immunol. 1986;137:1420-1428.

  2. Lanier LL, Phillips JH, Hackett J Jr, Tutt M, Kumar V. Natural killer cells: Definition of a cell type rather than a function. J Immunol. 1986;137:2735.

  3. Maino VC, Suni MA, Ruitenberg JJ. Rapid flow cytometric method for measuring lymphocyte subset activation. Cytometry. 1995;20:127-133.

  4. Meuer SC, Hussey RE, Fabbi M, et al. An alternative pathway of T cell activation: A functional role for the 50 kD T11 sheep erythrocyte receptor protein. Cell. 1984;36:897.

  5. Meuer SC. Cluster report: CD2. In: Knapp W, Dörken B, Gilks WR, et al, eds. Leucocyte Typing IV: White Cell Differentiation Antigens. New York, NY: Oxford University Press; 1989:270-272.

  6. Parish CR, McPhun V, Warren HS. Is a natural ligand of the T lymphocyte CD2 molecule a sulfated carbohydrate? J Immunol. 1988;141:3498-3504.

品牌介绍

BD是世界上最大的生产和销售医疗设备、医疗系统和试剂的医疗技术公司之一。致力于提高全世界人类的健康水平。BD专注于改进药物治疗,提高传染性疾病诊断的质量和速度,推进新型药物和疫苗的研究与发现。公司于1897年在纽约成立,总部位于美国新泽西州的富兰克林湖,业务可分为BD医疗、BD诊断、BD生物科学三大类,生产销售包括医用耗材、实验室仪器、抗体、试剂、诊断等产品。

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