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主营:医疗设备、医疗耗材、实验仪器、抗体、试剂、诊断等产品
℡ 4000-520-616
℡ 4000-520-616
BD Biosciences/Purified Mouse Anti-Human PAC-1/200µg/340535
产品编号:340535
市  场 价:¥8359.05
场      地:美国(厂家直采)
产品分类: 蛋白类>多肽>多肽合成>
联系QQ:1570468124
电话号码:4000-520-616
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美  元  价:$398.05
品      牌: BD Biosciences
公      司:BD Biosciences,Inc.
公司分类:
BD Biosciences/Purified Mouse Anti-Human PAC-1/200µg/340535
商品介绍
Product DetailsRecommended AssayReferences

Description

The PAC-1 antibody is derived from the fusion of SP-2 mouse myeloma cells with splenic lymphocytes from BALB/c mice that were immunized with human platelets.

The PAC-1 antibody recognizes an epitope on the glycoprotein IIb/IIIa (gpIIb/IIIa, αIIbβ3) complex of activated platelets at or near the platelet fibrinogen receptor.

Preparation and Storage

Store vials at 2°C–8°C. Conjugated forms should not be frozen. Protect from exposure to light. Each reagent is stable until the expiration date shown on the bottle label when stored as directed. Please refer to the vial label for antibody concentration.

  1. Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline — Third Edition. Wayne, PA: Clinical and Laboratory Standards Institute; 2005. CLSI document M29-A3.

  2. Abrams C, Deng Y-J, Steiner B, O’Toole T, Shattil SJ. Determinants of specificity of a baculovirus-expressed antibody Fab fragment that binds selectively to the activated form of integrin αIIb β3. J Biol Chem. 1994;269:18781-18788.

  3. Abrams C, Shattil SJ. Immunological detection of activated platelets in clinical disorders. Thrombosis and Haemostasis. 1991;65:467-473.

  4. Abrams CS, Ellison N, Budzinski AZ, Shattil SJ. Direct detection of activated platelets and platelet-derived microparticles in humans. Blood. 1990;75:128-138.

  5. Abrams CS, Ruggeri ZM, Taub R, et al. Anti-idiotypic antibodies against an antibody to the platelet glycoprotein (GP) IIb-IIIa complex mimic GP IIb-IIIa by recognizing fibrinogen. J Biol Chem. 1990;75:128-138.

  6. Bennett JS, Shattil SJ, Power JW, Gartner TK. Interaction of fibrinogen with its platelet receptor. J Biol Chem. 1988;263:12948-12953.

  7. Centers for Disease Control. Perspectives in disease prevention and health promotion update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in health-care settings. MMWR. 1988;37:377-388.

  8. Ginsberg MH, Frelinger AL, Lam S, et al. Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies. Blood. 1990;76:2017-2023.

  9. Huang M-M, Lipfert L, Cunningham M, et al. Adhesive ligand binding to integrin αIIbβ3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK. J Cell Biol. 1993;122:473-483.

  10. Hynes RO. Integrins: versatility, modulation, and signaling in cell adhesion. Cell. 1992;69:11-25.

  11. Michelson AD. Flow cytometry: A clinical test of platelet function. Blood. 1996;87:4925-4936.

  12. O’Toole TE, Mandelman D, Forsyth J, et al. Modulation of the affinity of integrin α IIb β 3 (GPIIb-IIIa) by the cytoplasmic domain of αIIb. Science. 1991;254:845-847.

  13. Shattil SJ, Cunningham M, Hoxie JA. Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow cytometry. Blood. 1987;70:307-315.

  14. Shattil SJ, Cunningham M. Wiedmer T, et al. Regulation of glycoprotein IIb-IIIa receptor function studied with platelets permeabilized by the pore-forming complement proteins C5b-9. J Biol Chem. 1992;267:18424-18431.

  15. Shattil SJ, Hoxie JA, Cunningham M, Brass L. Changes in the platelet membrane glycoprotein IIb-IIIa complex during platelet activation. J Biol Chem. 1985;260:11107-11114.

  16. Shattil SJ, Weisel JW, Kieber-Emmons T. Use of monoclonal antibodies to study the interaction between an integrin adhesion receptor, GP IIb-IIIa, and its physiological ligand, fibrinogen. Immunomethods. 1993;1:53-63.

  17. Springer TA. Adhesion receptors of the immune system. Nature. 1990;346:425-433.

  18. Taub R, Gould RJ, Garsky VM, et al. A monoclonal antibody against the platelet fibrinogen receptor contains a sequence that mimics a receptor recognition domain in fibrinogen. J Biol Chem. 1989;264:259-265.

品牌介绍

BD是世界上最大的生产和销售医疗设备、医疗系统和试剂的医疗技术公司之一。致力于提高全世界人类的健康水平。BD专注于改进药物治疗,提高传染性疾病诊断的质量和速度,推进新型药物和疫苗的研究与发现。公司于1897年在纽约成立,总部位于美国新泽西州的富兰克林湖,业务可分为BD医疗、BD诊断、BD生物科学三大类,生产销售包括医用耗材、实验室仪器、抗体、试剂、诊断等产品。

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